WebJan 12, 2005 · Flow cytometric analysis of freshly dispersed synovial cells indicated cadherin-11 expression predominantly on FLSs but not on cells of hematopoietic origin, including macrophage-like synoviocytes. Functional studies confirmed homophilic adhesive activity of cadherin-11 in FLSs. WebFeb 16, 2012 · In addition, the E-cadherin ligands CD103 and KLRG1 are expressed on DC-, T-, and NK-cell subsets and contribute to their interaction with E-cadherin …
Estradiol Promotes M1-like Macrophage Activation through …
WebFeb 15, 2015 · NR8383 macrophages were treated with estradiol and TNF-α, with or without blocking cadherin-11 or estrogen receptors, to evaluate the expression of the M1/M2-like macrophage-associated genes. We found that estradiol increased the infiltration of macrophages with a proinflammatory M1-like predominant profile in the synovium of … WebMay 17, 2024 · Macrophages play a critical role in joint inflammation by creating an imbalance between M1- and M2-polarized macrophages . M1 macrophages, which are activated by IFN-γ and lipopolysaccharide (LPS), are pro-inflammatory and are characterized by the production of TNF-α, IL-1β, IL-6 and inducible NO synthase (iNOS), … crailsheim aok
Identification and verification of the molecular mechanisms and ...
WebDec 8, 2024 · While cadherin (CDH) genes are aberrantly expressed in cancers, the functions of CDH genes in gastric cancer (GC) remain poorly understood. ... Tumor immune infiltration abundance of macrophage ... Webe under investigation and recently, cadherins have emerged as a potential therapeutic target on macrophages. The current review will discuss the importance of macrophages in SSc and fibrosis and summarize recent studies on the role of cadherin-11 (Cdh11) on macrophages and fibrosis. Recent findings Genome-wide expression studies … WebJul 7, 2016 · M0 and M1 macrophages had no effect on the MCF-7 epithelial phenotype. However, the M1 macrophages impacted the highly aggressive mesenchymal-like MDA-MB-231 breast cancer cells to take on a quiescent, epithelial phenotype with re-expression of E-cadherin. The M2 macrophages if anything exacerbated the mesenchymal … crailsheim alemania