WebTransient transfection studies revealed that constitutively active Akt1 up-regulated ERalpha at the post-transcriptional level. ... Transfection … WebFeb 18, 2014 · In contrast, Akt1 appears to play a significant role in viral gene transcription since cells overexpressing the dominant negative mutant Akt1 exhibited a significant decrease in viral gene transcription compared to cells overexpressing the constitutively active Akt1 (Fig. 2A). Enhanced viral protein synthesis was also observed in cells ...
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WebJun 3, 2024 · Constitutively active AKT1 induces NFKB1 activity, mediated by phosphorylation of IKK-alpha at threonine 23, which can be blocked by activated NIK. Conversely, NIK activation of NFKB1, mediated by phosphorylation of IKK-alpha at serine 176, is blocked by an AKT1 mutant lacking kinase activity (i.e., kinase-dead AKT), … WebAug 23, 2024 · The process of β-selection is also regulated by Notch, and the phenotype of Notch deletion can be rescued by constitutively active Akt1. Overall, studies of Akt … somarco for iron ore
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WebOct 10, 2003 · Akt1 Transgenic Mice—Transgenic mice overexpressing a constitutively active form of Akt1 (myrAkt1) in the heart were generated by crossing αMHC-tTA mice (36) with Tet-myrAkt1 mice, which express myrAkt1 under the control of tetracycline-responsive promoter. 2 Mice were maintained on doxycycline until 12 weeks of age, at which time ... WebSep 2, 2013 · A transgenic line in which constitutively active human AKT1 (caAKT1) is expressed from the rat probasin promoter develops HGPIN with high penetrance, but these tumors do not become invasive. 15 ... WebFeb 2, 2024 · Next, a constitutively active Akt1 (“ca-Akt1”, Flag-tagged) expression vector was introduced to H9c2 cells (see Method). Western blot assay results in Figure … somar dias power query