Ctcf p53
WebOct 1, 2001 · indirect 21 or direct 37 CTCF–p53 interactions. A third motif of potential importance, located. between the A T-hook and phosphorylation sites (Fig. 1c), contains two repeats of the PXXP-signature. WebMay 5, 2010 · CTCF knockdown leads to increased basal expression of PUMA concomitant with a reduction in chromatin boundary signatures. Importantly, derepression of PUMA upon CTCF depletion occurs without p53 activation or activation of other p53 target genes. Therefore, CTCF plays a pivotal role in dampening the p53 apoptotic response by acting …
Ctcf p53
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WebJul 20, 2024 · Download Citation CTCF promotes colorectal cancer cell proliferation and chemotherapy resistance to 5-FU via the P53-Hedgehog axis CTCF is overexpressed … WebMoreover, overexpression of CTCF in B-cell lymphoma leads to apoptosis, downregulation of c-Myc oncogene, and upregulation of P53 target genes. CTCF’s role in tumor suppression is further demonstrated in vivo using CTCF hemizygous knockout mice, which have a significantly higher chance to succumb to different types of cancer including uterine ...
WebFeb 19, 2014 · Increased p53 and PUMA levels in the Ctcf-null telencephalon. Both the Foxg1Cre and NestinCre models of CTCF loss exhibit increased levels of apoptosis, although the timing of onset differs between the two mutants. To investigate the molecular mechanism responsible for neuronal cell death due to CTCF loss, we assessed … http://genesdev.cshlp.org/content/28/7/723.full
WebApr 1, 2014 · Apart from its established role at the p53 promoter, CTCF regulates p53 expression through its physical interaction with Wrap53 RNA. Cells harboring a CTCF mutant in its RBR exhibit a defective p53 response to DNA damage. Moreover, the RBR facilitates CTCF multimerization in an RNA-dependent manner, which may bear directly … WebJan 10, 2003 · CTCF then acts through ARF, a direct transcriptional target, to activate p53 and its downstream target, p21. Direct interaction of CTCF with the promoter of p27 results in transcriptional activation (C.-F.Q., unpublished observations), a function that would synergize with down-regulation of MYC, a transcriptional repressor of p27 ( 36 ).
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WebJun 28, 2024 · The association of CTCF binding with RNAPII stalling at specific sites has been previously observed genome-wide in multiple cell lines , particularly at CTCF sites … port of nice francehttp://genesdev.cshlp.org/content/28/7/723.full#:~:text=Apart%20from%20its%20established%20role%20at%20the%20p53,exhibit%20a%20defective%20p53%20response%20to%20DNA%20damage. iron hem tapeWeb代謝產物活化蛋白(CAP,Catabolite activator protein),也稱為cAMP受體蛋白(CRP,cAMP Receptor Protein),為一種轉錄促進劑,以同型二聚體的方式存在。 其在結合上DNA時會同時彎曲DNA結構,促進RNA聚合酶的結合,加快轉錄速度。. 其結合在 乳糖操作子 ( 英语 : lac operon ) 的啟動子上後,會促進該操作子的轉錄。 port of nigg contactWebSep 29, 2024 · The transcription factor p53 is a tumor suppressor gene that plays an important role in regulating cell growth, apoptosis, and DNA repair. Mutations in the p53 gene occur in half of all human malignant tumors ( 7 – 9 ). In recent years, evidence indicates that p53 plays a protective role in inflammatory response by inhibiting the ... port of nigg locationWebNov 25, 2024 · Using Hi-C data, we observe spatial coupling between differentially expressed genes and their differentially accessible regulatory elements and reveal two … iron helps bodyWeb本研究表明在p53缺陷细胞中wgd诱导染色质分离缺失(lcs),其特征表现为长染色体与短染色体之间分离的减少。 细胞中CTCF与H3K9me3的下调驱动LCS。 结果表明LCS启动染色质构象变化,最终导致致癌表观遗传和转录修饰,说明染色质变化是WGD驱动的癌症标志物。 iron henning union textWebApr 17, 2014 · CTCF is known to bind to and induce the transcription of TP53, and the CTCF binding site in the TP53 promoter overlaps with the first intron of WRAP53 on the opposite DNA strand, suggesting that ... iron hemp