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WebNov 1, 2024 · Experts aren't certain about the mechanisms by which SSRIs lead to weight gain, but there are some theories. It may be that the drugs trigger changes in metabolism that cause the body to use calories less efficiently, or that they affect the appetite, leading to overeating. 9. Another hypothesis is that weight gained while taking an SSRI may be ... WebApr 18, 2024 · An improved mood while taking an antidepressant, for example, may increase your appetite, leading to weight gain. Don’t stop taking your drug right away even if you do gain a little bit of weight. WebNov 17, 2024 · Overeating or inactivity as a result of depression can cause weight gain. Some people lose weight as part of their depression. In turn, an improved appetite … m\u0026l electrical cape town